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Concept

Concept_relationshi

p

Concept_ancestor

Vocabulary

Source_to_concept_

map

Relationship

Concept_synonym

Drug_strength

Cohort_definition

Standardized vocabularies

Attribute_definition

Domain

Concept_class

Cohort

Dose_era

Condition_era

Drug_era

Cohort_attribut

e

Standardized

derived elements

Standardized clinical data

Drug_exposure

Condition_occurrenc

e

Procedure_occurrenc

e

Visit_occurrence

Measurement

Observation_period

Payer_plan_period

Provider

Care_siteLocation

Death

Cost

Device_exposure

Observation

Note

Standardized health system

data

Fact_relationship

Specimen

CDM_source

Standardized

meta-data

Standardized

health

economics

Person

Japa

n

North

America

Chin

a

Australi

a

Europ

e

Switzerla

nd

Ital

y

Indi

a

So

Africa

Isra

el

UK

Analytical

method:

Adherence to Drug

Application

to data

One SAS or R

script for each

study

• Not scalable

• Expensive

• Slow

• Prohibitive to

non-expert

routine use

North America Southeast Asia

China

Europe UK Japan

India

So Africa Switzerland Italy

Israel

Mortality

Adherence

Safety

Signals

Source of

Business

Standardize

d data

Standardized methods: ATLAS

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China

Europe UK Japan

India

So Africa Switzerland Italy

Israel

North America Southeast Asia

China

Europe UK Japan

India

So Africa Switzerland Italy

Israel

China

EMR Asset

EMR Asset

Claims

Asset

Claims

Asset

Claims

Asset

EMR AssetEMR Asset

EMR Asset

Claims

Asset

Claims

Asset

EMR

EMR

EMR

EMR

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